Coach options, experiment with % run vs pass tendancies and aggressiveness associated with them. -
Try adjusting the sliders and see what affect the changes have by simming several games... then quit without saving untill you find the right formula for your particular mix of talent. - Don't forget to check your players stamina... you might want to adjust the sub-in / sub-out slider as well.
Once you find the 'best settings', sim your season and take it as it comes. Nothing magic here, your players are on their own once you have made your decision as coach. The players do the rest.
If you can't beat them, you haven't discovered their weakness yet. - It's there... find it.
Sometimes, You can't see the forest for the trees!